Congeneric lantibiotics from ribosomal in vivo peptide synthesis with noncanonical amino acids

Expanded repetoire: Synthetic amino acids translated into propeptides dramatically increase the chemical diversity of the two-component lantibiotic lichenicidin. This opens new routes towards novel and unique peptide antibiotic sequences, which could display features important for medical applicatio...

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Bibliographic Details
Main Author: Oldach, Florian (author)
Other Authors: Al Toma, Rashed (author), Kuthning, Anja (author), Caetano, Tânia (author), Mendo, Sónia (author), Budisa, Nediljko (author), Süssmuth, Roderich D. (author)
Format: article
Language:eng
Published: 2019
Subjects:
In vivo peptide synthesis
Lantibiotics
Lichenicidin
Noncanonical amino acid
Peptide antibiotics
Online Access:http://hdl.handle.net/10773/26608
Country:Portugal
Oai:oai:ria.ua.pt:10773/26608
Description
Summary:Expanded repetoire: Synthetic amino acids translated into propeptides dramatically increase the chemical diversity of the two-component lantibiotic lichenicidin. This opens new routes towards novel and unique peptide antibiotic sequences, which could display features important for medical applications.

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