Synthesis, antiangiogenesis evaluation and molecular docking studies of 1-Aryl-3-[(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas: Discovery of a new substitution pattern for type II VEGFR-2 Tyr kinase inhibitors

The synthesis and biological evaluation of novel 1-aryl-3-[2-, 3- or 4-(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas 3, 4 and 5 as VEGFR-2 tyrosine kinase inhibitors, are reported. The 1-aryl-3-[3-(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas 4a-4h, with the arylurea in the meta position to the thioethe...

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Bibliographic Details
Main Author: Machado, Vera A. (author)
Other Authors: Peixoto, D. (author), Costa, R. (author), Froufe, H. J. C. (author), Calhelha, Ricardo C. (author), Abreu, R. M. V (author), Ferreira, Isabel C. F. R. (author), Soares, R. (author), Queiroz, Maria João R. P. (author)
Format: article
Language:eng
Published: 2015
Subjects:
Thienopyridinethioether 1,3-diarylureas
VEGFR-2 tyrosine kinase inhibitors
Enzymatic assays
Molecular Docking
HUVECs
Antiangiogenesis assays
Western blotting
Ciências Médicas::Outras Ciências Médicas
Ciências Naturais::Ciências Químicas
Science & Technology
Online Access:http://hdl.handle.net/1822/39853
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/39853

Internet

http://hdl.handle.net/1822/39853

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