The ceramide activated protein phosphatase Sit4 impairs sphingolipid dynamics, mitochondrial function and lifespan in a yeast model of Niemann-Pick type C1

The Niemann-Pick type C is a rare neurodegenerative disease that results from loss-of-function point mutations in NPC1 or NPC2, which affect the homeostasis of sphingolipids and sterols in human cells. We have previously shown that yeast lacking Ncr1, the orthologue of human NPC1 protein, display a...

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Bibliographic Details
Main Author: Vilaça, R (author)
Other Authors: Barros, I (author), Matmati, N (author), Silva, E (author), Teixeira, V (author), Hannun, YA (author), Costa, V (author)
Format: article
Language:eng
Published: 2018
Subjects:
Ceramide
Mitochondria
Niemann-Pick type
Sch9
Sit4
Sphingolipid signaling
Online Access:http://hdl.handle.net/10216/109382
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/109382

Internet

http://hdl.handle.net/10216/109382

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