The influence of genetic stability on Aspergillus fumigatus virulence and azole resistance

Genetic stability is extremely important for the survival of every living organism, and a very complex set of genes has evolved to cope with DNA repair upon DNA damage. Here, we investigated the Aspergillus fumigatus AtmA (Ataxia-telangiectasia mutated, ATM) and AtrA kinases, and how they impact vir...

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Bibliographic Details
Main Author: Reis, Thaila Fernanda dos (author)
Other Authors: Silva, Lilian Pereira (author), Castro, Patrícia Alves (author), Lima, Pollyne Borborema Almeida de (author), Carmo, Rafaela Andrade do (author), Marini, Marjorie Mendes (author), Silveira, José Franco da (author), Ferreira, Beatriz Henriques (author), Rodrigues, Fernando José dos Santos (author), Malavazi, Iran (author), Goldman, Gustavo Henrique (author)
Format: article
Language:eng
Published: 2018
Subjects:
Aspergillus fumigatus
ATM
ATR
azoles
DNA damage
Galleria mellonela
genetic instability
virulence
voriconazole
PFGE
Science & Technology
Online Access:http://hdl.handle.net/1822/50270
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/50270

Internet

http://hdl.handle.net/1822/50270

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