Optimal time for constant drug infusion initialization in neuromuscular blockade control
This paper presents a control strategy for neuromuscular blockade (NMB) level, in order to determine the optimal time to initialize the administration of the muscle relaxant rocuronium by means of the continuous infusion of a constant dose. The constant value of muscle relaxant for a particular pati...
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| Outros Autores: | , |
| Formato: | book |
| Idioma: | eng |
| Publicado em: |
2014
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| Assuntos: | |
| Texto completo: | https://repositorio-aberto.up.pt/handle/10216/110088 |
| País: | Portugal |
| Oai: | oai:repositorio-aberto.up.pt:10216/110088 |
| Resumo: | This paper presents a control strategy for neuromuscular blockade (NMB) level, in order to determine the optimal time to initialize the administration of the muscle relaxant rocuronium by means of the continuous infusion of a constant dose. The constant value of muscle relaxant for a particular patient undergoing general anesthesia is computed in order to guarantee that the steady-state value of neuromuscular blockade level is the desired reference value. In order to apply this open-loop control strategy, the patient's NMB response to rocuronium is assumed to be modeled by a recently proposed parameter parsimonious model. |
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