Anti-tumoral effect of the non-nucleoside DNMT inhibitor RG108 in human prostate cancer cells

Background: Current therapeutic strategies for advanced prostate cancer (PCa) are largely ineffective. Because aberrant DNA methylation associated with inappropriate gene-silencing is a common feature of PCa, DNA methylation inhibitors might constitute an alternative therapy. In this study we aimed...

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Bibliographic Details
Main Author: Pinho dos Santos Graça, Maria Inês (author)
Other Authors: Sousa, Elsa Joana (author), Baptista, Tiago (author), Almeida, Mafalda (author), Ramalho-Carvalho, João (author), Palmeira, Carlos (author), Henrique, Rui (author), Jerónimo, Carmen (author)
Format: article
Language:eng
Published: 2014
Subjects:
Prostate cancer
RG108
DNA methyltransferases
Proliferation
Apoptosis
Online Access:http://hdl.handle.net/10400.22/3844
Country:Portugal
Oai:oai:recipp.ipp.pt:10400.22/3844

Internet

http://hdl.handle.net/10400.22/3844

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