The redox state of cytochrome C modulates resistance to methotrexate in human MCF7 breast cancer cells
BACKGROUND: Methotrexate is a chemotherapeutic agent used to treat a variety of cancers. However, the occurrence of resistance limits its effectiveness. Cytochrome c in its reduced state is less capable of triggering the apoptotic cascade. Thus, we set up to study the relationship among redox state...
| Main Author: | |
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| Other Authors: | , , , , , |
| Format: | article |
| Language: | eng |
| Published: |
2018
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| Online Access: | http://hdl.handle.net/10773/24576 |
| Country: | Portugal |
| Oai: | oai:ria.ua.pt:10773/24576 |