Osteoconductive scaffolds obtained by means of in situ surface functionalization of wet-spun fibre meshes for bone regeneration applications

The success of bone tissue engineering (TE) strategies is strongly dependent on the development of new synthetic materials com- bining osteoconductive, osteoinductive and osteogenic properties. Recent studies suggest that biomaterials incorporating silanol groups promote and maintain osteogenesis wi...

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Detalhes bibliográficos
Autor principal: Rodrigues, M. T. (author)
Outros Autores: Leonor, I. B. (author), Viegas, C. A. A. (author), Dias, I. R. (author), Gomes, Manuela E. (author), Reis, R. L. (author)
Formato: conferenceObject
Idioma:eng
Publicado em: 2008
Assuntos:
Goat marrow stromal cells
Osteoconductive materials
Silanol groups
Starch-based polymers
Engenharia e Tecnologia::Biotecnologia Industrial
Science & Technology
Texto completo:http://hdl.handle.net/1822/58572
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/58572
Descrição
Resumo:The success of bone tissue engineering (TE) strategies is strongly dependent on the development of new synthetic materials com- bining osteoconductive, osteoinductive and osteogenic properties. Recent studies suggest that biomaterials incorporating silanol groups promote and maintain osteogenesis with or without bio- logical stimuli. This study aims to evaluate the osteoconductivity and osteogenic properties of novel wet-spun fibre mesh scaffolds of SPCL (blend of starch with polycaprolactone) with or without superficial functionalized silanol (Si-OH) groups by seeding/culturing them with goat marrow stromal cells (GBMCs)

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