Mutant Ataxin-2 expression in aged animals aggravates neuropathological features associated with Spinocerebellar Ataxia type 2

Spinocerebellar ataxia type 2 (SCA2) is a rare autosomal, dominantly inherited disease, in which the affected individuals have a disease onset around their third life decade. The molecular mechanisms underlying SCA2 are not yet completely understood, for which we hypothesize that aging plays a role...

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Bibliographic Details
Main Author: Afonso, Inês T. (author)
Other Authors: Lima, Patrícia (author), Conceição, André (author), Matos, Carlos A (author), Nóbrega, Clévio (author)
Format: article
Language:eng
Published: 2022
Subjects:
Online Access:http://hdl.handle.net/10400.1/18390
Country:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/18390