Vaccination models and optimal control strategies to dengue

As the development of a dengue vaccine is ongoing, we simulate an hypothetical vaccine as an extra protection to the population. In a first phase, the vaccination process is studied as a new compartment in the model, and different ways of distributing the vaccines investigated: pediatric and random...

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Bibliographic Details
Main Author: Rodrigues, H.S. (author)
Other Authors: Monteiro, M.T.T. (author), Torres, D.F.M. (author)
Format: article
Language:eng
Published: 1000
Subjects:
Online Access:http://hdl.handle.net/10773/11794
Country:Portugal
Oai:oai:ria.ua.pt:10773/11794
Description
Summary:As the development of a dengue vaccine is ongoing, we simulate an hypothetical vaccine as an extra protection to the population. In a first phase, the vaccination process is studied as a new compartment in the model, and different ways of distributing the vaccines investigated: pediatric and random mass vaccines, with distinct levels of efficacy and durability. In a second step, the vaccination is seen as a control variable in the epidemiological process. In both cases, epidemic and endemic scenarios are included in order to analyze distinct outbreak realities. © 2013 Elsevier Inc.