A transcritical bifurcation in an immune response model

The consequences of regulatory T cell (Treg) inhibition of interleukine 2 secretion are examined by mathematical modelling. We find a transcritical bifurcation that might explain two alternative scenarios: in one case the appearance of autoimmune responses and in another the suppression of the immun...

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Detalhes bibliográficos
Autor principal: Burroughs, NJ (author)
Outros Autores: Ferreira, M (author), Bruno M P M Oliveira (author), Alberto A. Pinto (author)
Formato: article
Idioma:eng
Publicado em: 2011
Assuntos:
Texto completo:https://hdl.handle.net/10216/94184
País:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/94184
Descrição
Resumo:The consequences of regulatory T cell (Treg) inhibition of interleukine 2 secretion are examined by mathematical modelling. We find a transcritical bifurcation that might explain two alternative scenarios: in one case the appearance of autoimmune responses and in another the suppression of the immune response.