Tacripyrines, the First Tacrine-Dihydropyridine Hybrids, as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease

Tacripyrines (1-14) have been designed by combining an ACNE inhibitor (tacrine) with a calcium antagonist such as nimodipine and are targeted to develop a multitarget therapeutic strategy to confront AD. Tacripyrines are selective and potent ACNE inhibitors in the nanomolar range. The mixed type inh...

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Bibliographic Details
Main Author: Marco-Contelles, Jose (author)
Other Authors: Leon, Rafael (author), de los Rios, Cristobal (author), Samadi, Abdelouahid (author), Bartolini, Manuela (author), Andrisano, Vincenza (author), Huertas, Oscar (author), Barril, Xavier (author), Javier Luque, F. (author), Rodriguez-Franco, Maria I. (author), Lopez, Beatriz (author), Lopez, Manuela G. (author), Garcia, Antonio G. (author), do Carmo Carreiras, Maria (author), Villarroya, Mercedes (author)
Format: article
Language:eng
Published: 2015
Subjects:
Chemistry, Medicinal
Online Access:http://hdl.handle.net/10451/21385
Country:Portugal
Oai:oai:repositorio.ul.pt:10451/21385

Internet

http://hdl.handle.net/10451/21385

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