Genomic-based surveillance reveals high ongoing transmission of multi-drug-resistant Mycobacterium tuberculosis in Southern Brazil

Funding Information: Funding: This study was funded, in part, by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (Grant No. 001) and supported by Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (Grant No. 17/1265–8 INCT-TB). JP is supported by Fundação para a Ci...

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Main Author: Salvato, Richard Steiner (author)
Other Authors: Reis, Ana Júlia (author), Schiefelbein, Sun Hee (author), Gómez, Michael Andrés Abril (author), Salvato, Stéphanie Steiner (author), da Silva, Larissa Vitória (author), Costa, Elis Regina Dalla (author), Unis, Gisela (author), Dias, Claudia Fontoura (author), Viveiros, Miguel (author), Portugal, Isabel (author), von Groll, Andrea (author), da Silva, Pedro Eduardo Almeida (author), Kritski, Afrânio Lineu (author), Perdigão, João (author), Rossetti, Maria Lucia Rosa (author)
Format: article
Language:eng
Published: 2022
Subjects:
Drug resistance
Transmission
Tuberculosis
Whole-genome sequencing
Microbiology (medical)
Infectious Diseases
Pharmacology (medical)
SDG 3 - Good Health and Well-being
SDG 12 - Responsible Consumption and Production
SDG 17 - Partnerships for the Goals
Microbiologia Médica
Online Access:http://hdl.handle.net/10362/133338
Country:Portugal
Oai:oai:run.unl.pt:10362/133338
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Summary:Funding Information: Funding: This study was funded, in part, by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (Grant No. 001) and supported by Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (Grant No. 17/1265–8 INCT-TB). JP is supported by Fundação para a Ciência e Tecnologia through Estímulo Individual ao Emprego Científico (CEECIND/00394/2017). Funding Information: The authors wish to thank TGen, C-Path and ReSeqTB for supporting WGS, and the Brazilian Network of Tuberculosis Research for enabling this partnership. The authors would also like to thank the Mycobacteria Laboratory at LACEN-RS/CEVS/SES-RS for performing and providing information on drug susceptibility testing. Funding: This study was funded, in part, by the Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - Brasil (Grant No. 001) and supported by Funda??o de Amparo ? Pesquisa do Estado do Rio Grande do Sul (Grant No. 17/1265?8 INCT-TB). JP is supported by Funda??o para a Ci?ncia e Tecnologia through Est?mulo Individual ao Emprego Cient?fico (CEECIND/00394/2017). Competing interests: None declared. Ethical approval: This project was approved by the Research Ethics Committee of the Funda??o Estadual de Produ??o e Pesquisa em Sa?de (Protocol No. 1.587.621 CAAE: 18269313.0.0000.5320). Data availability: M. tuberculosis genome data were deposited in the NCBI BioProject database (IDs: PRJNA535343, PRJNA639713 and PRJNA692642). Individual accession numbers for genomes analysed in this study are given in the online supplementary material. Publisher Copyright: © 2021 Elsevier Ltd

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