Differential gene expression in cells from Fabry and Gaucher diseases: cell reprogramming and culture aging

Gene expression varies deeply, even in the same individual’s cells, depending on stress factors, cell aging, gene variants or gene and cell manipulation In this work, gene expression can be seen to shift in many genes, using fibroblasts from donors with Fabry and Gaucher type 3 genetic diseases Test...

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Bibliographic Details
Main Author: Amaral, Olga (author)
Other Authors: Santos, Renato (author), Ribeiro, Diogo (author)
Format: conferenceObject
Language:eng
Published: 2020
Subjects:
Gene Expression
iPSCs
RNA
Cell Models
Lysosomal Disorders
Fabry Disease
Gaucher disease
Doenças Genéticas
Genética Humana
Online Access:http://hdl.handle.net/10400.18/6798
Country:Portugal
Oai:oai:repositorio.insa.pt:10400.18/6798
Description
Summary:Gene expression varies deeply, even in the same individual’s cells, depending on stress factors, cell aging, gene variants or gene and cell manipulation In this work, gene expression can be seen to shift in many genes, using fibroblasts from donors with Fabry and Gaucher type 3 genetic diseases Tests were also made to compare the impact of aging cultures Real time qRT PCR protocols for genes of interest were used for expression comparison after cell induction and reprogramming.

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