Synthesis of some novel pyrazolo[3,4-d]pyrimidine derivatives
Reaction of ethyl imidates derived from N-aryl-5-amino-4-cyanopyrazoles with amines or arylhydrazines gave only 4-substituted pyrazolo[3,4-d]pyrimidines, resulting from cyclization followed by Dimroth rearrangement. From the reaction with arylhydrazines, a mixture of the hydrazines and their oxidize...
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| Other Authors: | , |
| Format: | article |
| Language: | eng |
| Published: |
2007
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| Subjects: | |
| Online Access: | http://hdl.handle.net/1822/8647 |
| Country: | Portugal |
| Oai: | oai:repositorium.sdum.uminho.pt:1822/8647 |
| Summary: | Reaction of ethyl imidates derived from N-aryl-5-amino-4-cyanopyrazoles with amines or arylhydrazines gave only 4-substituted pyrazolo[3,4-d]pyrimidines, resulting from cyclization followed by Dimroth rearrangement. From the reaction with arylhydrazines, a mixture of the hydrazines and their oxidized forms, the azo products, was obtained. This was proven by an independent synthesis starting from the corresponding 4-chloropyrazolo[3,4-d]pyrimidines as starting material. The structures of the compounds obtained were confirmed by mass spectrometry, 1H and 13C NMR. |
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