Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas

Background: Glioblastomas (GBM) present a high cellular heterogeneity with conspicuous necrotic regions associated with hypoxia, which is related to tumor aggressiveness. GBM tumors exhibit high glycolytic metabolism with increased lactate production that is extruded to the tumor microenvironment th...

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Bibliographic Details
Main Author: Gonçalves, Vera Mónica Miranda (author)
Other Authors: Granja, Sara Costa (author), Martinho, Olga (author), Honavar, Mrinalini (author), Pojo, Marta (author), Costa, Bruno Marques (author), Pires, Manuel Melo (author), Pinheiro, Célia (author), Reis, R. M. (author), Baltazar, Fátima (author)
Format: article
Language:eng
Published: 2016
Subjects:
Monocarboxylate transporters (MCTs)
Tumor hypoxia
Lactate
Glioblastomas
Warburg effect
Science & Technology
Online Access:http://hdl.handle.net/1822/45059
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/45059

Internet

http://hdl.handle.net/1822/45059

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