Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas

Background: Glioblastomas (GBM) present a high cellular heterogeneity with conspicuous necrotic regions associated with hypoxia, which is related to tumor aggressiveness. GBM tumors exhibit high glycolytic metabolism with increased lactate production that is extruded to the tumor microenvironment th...

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Detalhes bibliográficos
Autor principal: Gonçalves, Vera Mónica Miranda (author)
Outros Autores: Granja, Sara Costa (author), Martinho, Olga (author), Honavar, Mrinalini (author), Pojo, Marta (author), Costa, Bruno Marques (author), Pires, Manuel Melo (author), Pinheiro, Célia (author), Reis, R. M. (author), Baltazar, Fátima (author)
Formato: article
Idioma:eng
Publicado em: 2016
Assuntos:
Monocarboxylate transporters (MCTs)
Tumor hypoxia
Lactate
Glioblastomas
Warburg effect
Science & Technology
Texto completo:http://hdl.handle.net/1822/45059
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/45059

Texto Completo

http://hdl.handle.net/1822/45059

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