QSAR-driven design and discovery of novel compounds with antiplasmodial and transmission blocking activities

Malaria is a life-threatening infectious disease caused by parasites of the genus Plasmodium, affecting more than 200 million people worldwide every year and leading to about a half million deaths. Malaria parasites of humans have evolved resistance to all current antimalarial drugs, urging for the...

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Bibliographic Details
Main Author: Lima, Marilia N.N. (author)
Other Authors: Melo-Filho, Cleber C. (author), Cassiano, Gustavo C. (author), Neves, Bruno J. (author), Alves, Vinicius M. (author), Braga, Rodolpho C. (author), Cravo, Pedro V.L. (author), Muratov, Eugene N. (author), Calit, Juliana (author), Bargieri, Daniel Y. (author), Costa, Fabio T.M. (author), Andrade, Carolina H. (author)
Format: article
Language:eng
Published: 2021
Subjects:
DUTPase
Malaria
Plasmodium falciparum
QSAR
Transmission blocker
Virtual screening
Pharmacology
Pharmacology (medical)
Drug Discovery
SDG 3 - Good Health and Well-being
Online Access:http://hdl.handle.net/10362/116841
Country:Portugal
Oai:oai:run.unl.pt:10362/116841

Internet

http://hdl.handle.net/10362/116841

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