Cancer-specific mutations in p53 induce the translation of Δ160p53 promoting tumorigenesis
Wild-type p53 functions as a tumour suppressor while mutant p53 possesses oncogenic potential. Until now it remains unclear how a single mutation can transform p53 into a functionally distinct gene harbouring a new set of original cellular roles. Here we show that the most common p53 cancer mutants...
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| Outros Autores: | , |
| Formato: | article |
| Idioma: | eng |
| Publicado em: |
2017
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| Assuntos: | |
| Texto completo: | http://hdl.handle.net/10400.18/4395 |
| País: | Portugal |
| Oai: | oai:repositorio.insa.pt:10400.18/4395 |