Protein conformational flexibility modulates kinetics and thermodynamics of drug binding

Structure-based drug design has often been restricted by the rather static picture of protein-ligand complexes presented by crystal structures, despite the widely accepted importance of protein flexibility in biomolecular recognition. Here we report a detailed experimental and computational study of...

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Bibliographic Details
Main Author: Amaral, Marta (author)
Other Authors: Kokh, D. B. (author), Bomke, J. (author), Wegener, A. (author), Buchstaller, H. P. (author), Eggenweiler, H. M. (author), Matias, P. (author), Sirrenberg, C. (author), Wade, R. C. (author), Frech, M. (author)
Format: article
Language:eng
Published: 2019
Subjects:
Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)
Online Access:https://doi.org/10.1038/s41467-017-02258-w
Country:Portugal
Oai:oai:run.unl.pt:10362/85347

Internet

https://doi.org/10.1038/s41467-017-02258-w

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