Impact of the Pd2Spermine Chelate on Osteosarcoma Metabolism: An NMR Metabolomics Study

A metabolomics study of Pd2Spermine(Spm) on osteosarcoma MG-63 and osteoblastic HOb cells is presented to assess the impact of the potential palladium drug on cell metabolism compared with cisplatin (cDDP). Despite its higher cytotoxicity, Pd2Spm induced lower (and reversible) metabolic impact on MG...

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Detalhes bibliográficos
Autor principal: Lamego, Inês (author)
Outros Autores: Marques, M. Paula M. (author), Duarte, Iola F. (author), Martins, Ana S. (author), Oliveira, Helena (author), Gil, Ana M. (author)
Formato: article
Idioma:eng
Publicado em: 2017
Assuntos:
Amino Acids
Antineoplastic Combined Chemotherapy Protocols
Apoptosis
Cell Line, Tumor
Cisplatin
Doxorubicin
Glycosylation
Humans
Lipid Metabolism
Magnetic Resonance Spectroscopy
Osteosarcoma
Palladium
Spermine
Metabolomics
Texto completo:http://hdl.handle.net/10316/45030
País:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/45030

Texto Completo

http://hdl.handle.net/10316/45030

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