Impact of the Pd2Spermine Chelate on Osteosarcoma Metabolism: An NMR Metabolomics Study

A metabolomics study of Pd2Spermine(Spm) on osteosarcoma MG-63 and osteoblastic HOb cells is presented to assess the impact of the potential palladium drug on cell metabolism compared with cisplatin (cDDP). Despite its higher cytotoxicity, Pd2Spm induced lower (and reversible) metabolic impact on MG...

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Bibliographic Details
Main Author: Lamego, Inês (author)
Other Authors: Marques, M. Paula M. (author), Duarte, Iola F. (author), Martins, Ana S. (author), Oliveira, Helena (author), Gil, Ana M. (author)
Format: article
Language:eng
Published: 2017
Subjects:
Amino Acids
Antineoplastic Combined Chemotherapy Protocols
Apoptosis
Cell Line, Tumor
Cisplatin
Doxorubicin
Glycosylation
Humans
Lipid Metabolism
Magnetic Resonance Spectroscopy
Osteosarcoma
Palladium
Spermine
Metabolomics
Online Access:http://hdl.handle.net/10316/45030
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/45030

Internet

http://hdl.handle.net/10316/45030

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