Reactivity of imidazolidin-4-one derivatives of primaquine

In contrast to peptide-based imidazolidin-4-ones, those synthesized from N-(alpha-aminoacyl) derivatives of the antimalarial drug, primaquine and ketones are unexpectedly stable in pH 7.4 at 37 degrees C. The kinetics of hydrolysis of primaquine-based imidazolidin-4-ones were investigated in the pH...

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Bibliographic Details
Main Author: Chambel, Paula (author)
Other Authors: Capela, Rita (author), Lopes, Francisca (author), Iley, Jim (author), Morais, Jose (author), Gouveia, Luis (author), Gomes, Jose R. B. (author), Gomes, Paula (author), Moreira, Rui (author)
Format: article
Language:eng
Published: 2015
Subjects:
Chemistry, Organic
Online Access:http://hdl.handle.net/10451/21196
Country:Portugal
Oai:oai:repositorio.ul.pt:10451/21196

Internet

http://hdl.handle.net/10451/21196

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