An insight into the synthesis of cationic porphyrin-imidazole derivatives and their photodynamic inactivation efficiency against Escherichia coli

New porphyrin-imidazole derivatives were synthesised by Radziszewski reaction between 2-formyl-5,10,15,20-tetraphenylporphyrin 1 and several (hetem)aromatic 1,2-diones, which after cationization afforded promising monocationic photosensitizers 3a-d. Singlet oxygen studies have demonstrated that all...

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Detalhes bibliográficos
Autor principal: Moreira, Xavier (author)
Outros Autores: Santos, Patricia (author), Faustino, M. Amparo F. (author), Raposo, M. Manuela M. (author), Costa, Susana P. G. (author), Moura, Nuno M. M. (author), Gomes, Ana T. P. C. (author), Almeida, Adelaide (author), Neves, M. G. P. M. S. (author)
Formato: article
Idioma:eng
Publicado em: 2020
Assuntos:
Porphyrin
N-Heterocycles
Photosensitizer
Antimicrobial photodynamic therapy
Gram-negative E. coli
Ciências Naturais::Ciências Químicas
Science & Technology
Texto completo:http://hdl.handle.net/1822/66002
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/66002
Descrição
Resumo:New porphyrin-imidazole derivatives were synthesised by Radziszewski reaction between 2-formyl-5,10,15,20-tetraphenylporphyrin 1 and several (hetem)aromatic 1,2-diones, which after cationization afforded promising monocationic photosensitizers 3a-d. Singlet oxygen studies have demonstrated that all the cationic porphyrin-imidazole conjugates 3a-d were capable to produce cytotoxic species. These photosensitizers were able to photoinactivate Eschericha coli and their inactivation profile was improved in the presence of KI.

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