SLMP53-1 interacts with wild-type and mutant p53 DNA-binding domain and reactivates multiple hotspot mutations

Background Half of human cancers harbour TP53 mutations that render p53 inactive as a tumor suppressor. As such, reactivation of mutant (mut)p53 through restoration of wild-type (wt)-like function represents one of the most promising therapeutic strategies in cancer treatment. Recently, we have repo...

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Bibliographic Details
Main Author: Gomes, A. S. (author)
Other Authors: Ramos, Helena (author), Gomes, S. (author), Loureiro, Joana B. (author), Soares, Joana (author), Barcherini, Valentina (author), Monti, Paola (author), Fronza, Gilberto (author), Oliveira, Carla Cristina Marques de (author), Domingues, Lucília (author), Bastos, Margarida (author), Dourado, Daniel F. A. R. (author), Carvalho, Ana Luísa (author), Romão, Maria João (author), Pinheiro, Benedita (author), Marcelo, Filipa (author), Carvalho, Alexandra (author), Santos, Maria M. M. (author), Saraiva, Lucília (author)
Format: article
Language:eng
Published: 2020
Subjects:
p53
Mutant
Cancer
Chemotherapy
Reactivator
Ciências Médicas::Biotecnologia Médica
Science & Technology
Online Access:http://hdl.handle.net/1822/62529
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/62529

Internet

http://hdl.handle.net/1822/62529

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