Prevalence and distribution of peripheral musculoskeletal manifestations in spondyloarthritis including psoriatic arthritis

Objectives: To characterise peripheral musculoskeletal involvement in patients with spondyloarthritis (SpA) including psoriatic arthritis (PsA), across the world. Methods: Cross-sectional study with 24 participating countries. Patients with a diagnosis of axial SpA (axSpA), peripheral SpA (pSpA) or...

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Bibliographic Details
Main Author: López-Medina, Clementina (author)
Other Authors: Molto, Anna (author), Sieper, Joachim (author), Duruöz, Tuncay (author), Kiltz, Uta (author), Elzorkany, Bassel (author), Hajjaj-Hassouni, Najia (author), Burgos-Vargas, Ruben (author), Maldonado-Cocco, José (author), Ziade, Nelly (author), Gavali, Meghna (author), Navarro-Compan, Victoria (author), Luo, Shue Fen (author), Monti, Sara (author), Tae-Jong, Kim (author), Kishimoto, Mitsumasa (author), Pimentel-Santos, F. M. (author), Gu, Jieruo (author), Schiotis, Ruxandra (author), Van Gaalen, Floris A. (author), Geher, Pál (author), Magrey, Marina (author), Ibáñez Vodnizza, Sebastián E. (author), Bautista-Molano, Wilson (author), Maksymowych, Walter (author), Machado, Pedro M. (author), Landewé, Robert (author), Van Der Heijde, Desirée (author), Dougados, Maxime (author)
Format: article
Language:eng
Published: 2021
Subjects:
ankylosing
arthritis
juvenile
psoriatic
spondylitis
Immunology and Allergy
Rheumatology
Immunology
Online Access:http://hdl.handle.net/10362/111519
Country:Portugal
Oai:oai:run.unl.pt:10362/111519
Description
Summary:Objectives: To characterise peripheral musculoskeletal involvement in patients with spondyloarthritis (SpA) including psoriatic arthritis (PsA), across the world. Methods: Cross-sectional study with 24 participating countries. Patients with a diagnosis of axial SpA (axSpA), peripheral SpA (pSpA) or PsA according to their rheumatologist were included. The investigators were asked which diagnosis out of a list of six (axSpA, PsA, pSpA, inflammatory bowel disease-associated SpA, reactive arthritis or juvenile SpA (Juv-SpA)) fitted the patient best. Peripheral manifestations (ie, peripheral joint disease, enthesitis, dactylitis and root joint disease), their localisation and treatments were evaluated. Results: A total of 4465 patients were included (61% men, mean age 44.5 years) from four geographic areas: Latin America (n=538), Europe plus North America (n=1677), Asia (n=975) and the Middle East plus North Africa (n=1275). Of those, 78% had ever suffered from at least one peripheral musculoskeletal manifestation; 57% had peripheral joint disease, 44% had enthesitis and 15% had dactylitis. Latin American had far more often peripheral joint disease (80%) than patients from other areas. Patients with PsA had predominantly upper limb and small joint involvement (52%). Hip and shoulder involvement was found in 34% of patients. The prevalence of enthesitis ranged between 41% in patients with axSpA and 65% in patients with Juv-SpA. Dactylitis was most frequent among patients with PsA (37%). Conclusion: These results suggest that all peripheral features can be found in all subtypes of SpA, and that differences are quantitative rather than qualitative. In a high proportion of patients, axial and peripheral manifestations coincided. These findings reconfirm SpA clinical subtypes are descendants of the same underlying disease, called SpA.

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