Covalent Histone Modification by an Electrophilic Derivative of the Anti-HIV Drug Nevirapine

Funding: This work was supported in part by the PRIME-XS project, grant agreement number 262067, funded by the European Union seventh Framework Programme. We also thank Fundação para a Ciência e a Tecnologia (FCT), Portugal, for financial support through projects UID/QUI/00100/2020 (to CQE), RECI/QE...

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Detalhes bibliográficos
Autor principal: Harjivan, Shrika G. (author)
Outros Autores: Charneira, Catarina (author), Martins, Inês L. (author), Pereira, Sofia A. (author), Espadas, Guadalupe (author), Sabidó, Eduard (author), Beland, Frederick A. (author), Marques, M. Matilde (author), Antunes, Alexandra M.M. (author)
Formato: article
Idioma:eng
Publicado em: 2021
Assuntos:
covalent histone modification
covalent protein adducts
drug-induced adverse reactions
mass spectrometry
nevirapine
Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry
SDG 3 - Good Health and Well-being
Texto completo:http://hdl.handle.net/10362/116017
País:Portugal
Oai:oai:run.unl.pt:10362/116017
Descrição
Resumo:Funding: This work was supported in part by the PRIME-XS project, grant agreement number 262067, funded by the European Union seventh Framework Programme. We also thank Fundação para a Ciência e a Tecnologia (FCT), Portugal, for financial support through projects UID/QUI/00100/2020 (to CQE), RECI/QEQ-MED/0330/2012 and PTDC/QUI-QAN/32242/2017, as well as contract CEECIND/02001/2017 (to A.M.M.A) and doctoral fellowships SFRH/BD/80690/2011 (to SGH), SFRH/BD/75426/2010 (to ILM), and SFRH/BD/102846/2014 (to CC). Joint funding from FCT and the COMPETE Program through grant SAICTPAC/0019/2015 and RNEM-LISBOA-01-0145- FEDER-022125 funding are also gratefully acknowledged. The CRG/UPF Proteomics Unit is part of the “Plataforma de Recursos Biomoleculares y Bioinformáticos (ProteoRed)” supported by grant PT13/0001 of the Instituto de Salud Carlos III (ISCIII).

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