Decavanadate interactions with actin: inhibition of G-actin polymerization and stabilization of decameric vanadate

Decameric vanadate species (V10) inhibit the rate and the extent of G-actin polymerization with an IC50 of 68 ± 22 lM and 17 ± 2 lM, respectively, whilst they induce F-actin depolymerization at a lower extent. On contrary, no effect on actin polymerization and depolymerization was detected for 2 mM...

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Bibliographic Details
Main Author: Ramos, Susana (author)
Other Authors: Manuel, Miguel (author), Tiago, Teresa (author), Duarte, Rui O. (author), Martins, Jorge (author), Gutiérrez-Merino, Carlos (author), Moura, José J. G. (author), Aureliano, M. (author)
Format: article
Language:eng
Published: 2012
Subjects:
Actin
Decavanadate
Online Access:http://hdl.handle.net/10400.1/1293
Country:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/1293

Internet

http://hdl.handle.net/10400.1/1293

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