MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegeneration

Background: MicroRNA (miRNA) expression in the brain is altered in neurodegenerative diseases. Recent studies demonstrated that selected miRNAs conventionally regulating gene expression at the post-transcriptional level can act extracellularly as signaling molecules. The identity of miRNA species se...

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Bibliographic Details
Main Author: Wallach, Thomas (author)
Other Authors: Mossmann, Zoé J. (author), Szczepek, Michal (author), Wetzel, Max (author), Machado, Rui (author), Raden, Martin (author), Miladi, Milad (author), Kleinau, Gunnar (author), Krüger, Christina (author), Dembny, Paul (author), Adler, Drew (author), Zhai, Yuanyuan (author), Kumbol, Victor (author), Dzaye, Omar (author), Schüler, Jutta (author), Futschik, Matthias (author), Backofen, Rolf (author), Scheerer, Patrick (author), Lehnardt, Seija (author)
Format: article
Language:eng
Published: 2021
Subjects:
Extracellular microRNAs
Endogenous Toll-like receptor ligands
Cortical neurons
Neuronal apoptosis
Microglia
Neurodegeneration
miRNA microarray
Online Access:http://hdl.handle.net/10400.1/17388
Country:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/17388

Internet

http://hdl.handle.net/10400.1/17388

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