MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegeneration

Background: MicroRNA (miRNA) expression in the brain is altered in neurodegenerative diseases. Recent studies demonstrated that selected miRNAs conventionally regulating gene expression at the post-transcriptional level can act extracellularly as signaling molecules. The identity of miRNA species se...

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Detalhes bibliográficos
Autor principal: Wallach, Thomas (author)
Outros Autores: Mossmann, Zoé J. (author), Szczepek, Michal (author), Wetzel, Max (author), Machado, Rui (author), Raden, Martin (author), Miladi, Milad (author), Kleinau, Gunnar (author), Krüger, Christina (author), Dembny, Paul (author), Adler, Drew (author), Zhai, Yuanyuan (author), Kumbol, Victor (author), Dzaye, Omar (author), Schüler, Jutta (author), Futschik, Matthias (author), Backofen, Rolf (author), Scheerer, Patrick (author), Lehnardt, Seija (author)
Formato: article
Idioma:eng
Publicado em: 2021
Assuntos:
Extracellular microRNAs
Endogenous Toll-like receptor ligands
Cortical neurons
Neuronal apoptosis
Microglia
Neurodegeneration
miRNA microarray
Texto completo:http://hdl.handle.net/10400.1/17388
País:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/17388

Texto Completo

http://hdl.handle.net/10400.1/17388

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