Compensatory T-Cell Regulation in Unaffected Relatives of SLE Patients, and Opposite IL-2/CD25-Mediated Effects Suggested by Coreferentiality Modeling

In human systemic lupus erythematosus (SLE), diverse autoantibodies accumulate over years before disease manifestation. Unaffected relatives of SLE patients frequently share a sustained production of autoantibodies with indiscriminable specificity, usually without ever acquiring the disease. We stud...

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Bibliographic Details
Main Author: Fesel, Constantin (author)
Other Authors: Barreto, Marta (author), Ferreira, Ricardo C. (author), Costa, Nuno (author), Venda, Lara L. (author), Pereira, Clara (author), Carvalho, Claudia (author), Morães-Fontes, Maria Francisca (author), Ferreira, Carlos M. (author), Vasconcelos, Carlos (author), Viana, João F. (author), Santos, Eugenia (author), Martins, Berta (author), Demengeot, Jocelyne (author), Vicente, Astrid M. (author)
Format: article
Language:eng
Published: 2016
Subjects:
Adolescent
Adult
Aged
Autoantibodies
CD4 Lymphocyte Count
Family
Female
Genotype
Humans
Immunoglobulin G
Interleukin-2
Interleukin-2 Receptor alpha Subunit
Lupus Erythematosus, Systemic
Male
Middle Aged
Phenotype
Protein Binding
T-Lymphocytes
T-Lymphocytes, Regulatory
Young Adult
Models, Immunological
Online Access:http://hdl.handle.net/10400.7/638
Country:Portugal
Oai:oai:arca.igc.gulbenkian.pt:10400.7/638

Internet

http://hdl.handle.net/10400.7/638

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