TP53 codon 72 polymorphism in susceptibility, overall survival, and adjuvant therapy response of gliomas.

TP53 is a key tumor suppressor gene that encodes a transcriptional factor involved in several cellular mechanisms, including growth arrest, DNA repair, and induction of apoptosis. In addition to TP53 gene mutations, a common polymorphism, Arg72Pro, has been involved in the carcinogenesis process. Th...

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Bibliographic Details
Main Author: Lima-Ramos, V (author)
Other Authors: Pacheco-Figueiredo, L (author), Costa, S (author), Pardal, F (author), Silva, A (author), Amorim, J (author), Lopes, JM (author), Reis, RM (author)
Format: article
Language:eng
Published: 2013
Subjects:
Neoplasias Cerebrais
Glioma
Predisposição Genética para Doença
Polimorfismo Genético
Genes p53
Online Access:http://hdl.handle.net/10400.23/451
Country:Portugal
Oai:oai:repositorio.hospitaldebraga.pt:10400.23/451

Internet

http://hdl.handle.net/10400.23/451

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