Nefropatia diabética: taxa de filtração glomerular calculada e estimada

OBJECTIVE: To assess in diabetic nephropathy, the accuracy of estimated creatinine clearance (calculated with the Cockroft Gault formula) and the clearance of the Tc99m-DTPA, to measure the glomerular filtration rate (GFR). PATIENTS AND METHODS: We analysed the GFR measure by Tc99m-DTPA method and t...

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Bibliographic Details
Main Author: Guimarães, J (author)
Other Authors: Bastos, M (author), Melo, M (author), Carvalheiro, M (author)
Format: article
Language:por
Published: 2008
Subjects:
Creatinina
Diabetes Mellitus Tipo 1
Diabetes Mellitus Tipo 2
Taxa de Filtração Glomerular
Online Access:http://hdl.handle.net/10400.4/212
Country:Portugal
Oai:oai:rihuc.huc.min-saude.pt:10400.4/212
Description
Summary:OBJECTIVE: To assess in diabetic nephropathy, the accuracy of estimated creatinine clearance (calculated with the Cockroft Gault formula) and the clearance of the Tc99m-DTPA, to measure the glomerular filtration rate (GFR). PATIENTS AND METHODS: We analysed the GFR measure by Tc99m-DTPA method and the estimated by the Cockroft Gault formula, in 21 subjects with type 1 or type 2 diabetes. RESULTS: There was a strong positive correlation between the two methods but the Cockroft Gault formula underestimated the GFR. CONCLUSIONS: The formula gives a accurate estimates of GFR, when GFR is <100 ml/min/1,73 m2. Beside the underestimation, the formula could be used in the management of diabetic nephropathy because the repeated isotope assessments of renal function are impracticable.

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