Somatic mitochondrial DNA mutations in cancer escape purifying selection and high pathogenicity mutations lead to the oncocytic phenotype: pathogenicity analysis of reported somatic mtDNA mutations in tumors

BACKGROUND: The presence of somatic mitochondrial DNA (mtDNA) mutations in cancer cells has been interpreted in controversial ways, ranging from random neutral accumulation of mutations, to positive selection for high pathogenicity, or conversely to purifying selection against high pathogenicity var...

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Bibliographic Details
Main Author: Pereira, L (author)
Other Authors: Soares, P (author), Máximo, V (author), Samuels, DC (author)
Format: article
Language:eng
Published: 2012
Subjects:
DNA Mitochondrial/genetics
Electron Transport Complex I/genetics
Humans
Mitochondrial Proteins/genetics
Mutation/genetics
Neoplasms/genetics
Phenotype
Phylogeny
Selection Genetic
Online Access:http://hdl.handle.net/10216/109256
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/109256

Internet

http://hdl.handle.net/10216/109256

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