Development of a QSAR models for the prediction of plasma protein binding

One of the most important factors, affecting the pharmacokinetic profile of a drug is binding to plasma protein. As such, this study aimed at the development of a quantitative structure–activity relationship model, to predict the fraction unbound in plasma (fub) for four species, using artificial ne...

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Bibliographic Details
Main Author: Poiares, João Pedro da Silva Gonçalves (author)
Format: masterThesis
Language:eng
Published: 2014
Subjects:
Online Access:http://hdl.handle.net/10437/5858
Country:Portugal
Oai:oai:recil.ensinolusofona.pt:10437/5858