Modulation of translation factor's gene expression by histone deacetylase inhibitors in breast cancer cells

The histone deacetylase inhibitors sodium butyrate (NaBu) and trichostatin A (TSA) exhibit anti-proliferative activity by causing cell cycle arrest and apoptosis. The mechanisms by which NaBu and TSA cause apoptosis and cell cycle arrest are not yet completely clarified, although these agents are kn...

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Bibliographic Details
Main Author: Gonçalves, João (author)
Other Authors: Malta-Vacas, Joana (author), Louis, Monette (author), Brault, Laurent (author), Bagrel, Denyse (author), Monteiro, Carolino (author), Brito, Miguel (author)
Format: article
Language:eng
Published: 2014
Subjects:
Pharmacology
Antineoplastic agents
Apoptosis
Breast neoplasms
Butyrates
Cell cycle
Enzyme inhibitors
Gene expression regulation
Genes, Neoplasm
Histone deacetylase inhibitors
Hydroxamic acids
Peptide chain elongation, Translational
Protein biosynthesis
Tumor cells, Cultured
Online Access:http://hdl.handle.net/10400.21/3075
Country:Portugal
Oai:oai:repositorio.ipl.pt:10400.21/3075

Internet

http://hdl.handle.net/10400.21/3075

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