Enhanced solid-state stability of amorphous ibrutinib formulations prepared by hot-melt extrusion

One of the applications of Hot-Melt Extrusion (HME) is the stabilization of amorphous drugs through its incorporation into polymeric blends in the form of Amorphous Solid Dispersions (ASDs). In this study, HME was applied to solve a real problem in the development of an ibrutinib product, stabilizin...

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Bibliographic Details
Main Author: Simões, Marta F. (author)
Other Authors: Nogueira, Bernardo A. (author), Tabanez, Andreia M. (author), Rui Fausto (author), Pinto, Rui M. A. (author), Simões, Sérgio (author)
Format: article
Language:eng
Published: 2020
Subjects:
Amorphous solid dispersions
Hot-melt extrusion
Ibrutinib
Multivariate statistics
Polymers
Principal components analysis
Online Access:http://hdl.handle.net/10316/91157
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/91157

Internet

http://hdl.handle.net/10316/91157

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