The interplay between mRNA translation and nonsense-mediated decay in AUG-proximal nonsense-mutated transcripts
Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that recognizes and rapidly degrades mRNAs containing premature termination codons (PTC). The unified model for NMD, proposes that the decision of NMD triggering is the outcome of the competition between the cytoplasmatic poly(A)-binding p...
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| Format: | lecture |
| Language: | eng |
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2015
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| Online Access: | http://hdl.handle.net/10400.18/2716 |
| Country: | Portugal |
| Oai: | oai:repositorio.insa.pt:10400.18/2716 |