Macrophage iron metabolism profile in proatherogenic conditions
Atherosclerosis is currently considered as a chronic inflammatory disease, in which the subendothelial accumulation of macrophages and their differentiation in lipid−laden foam cells through the uptake of oxidized LDL (oxLDL) constitute key events in atherogenesis [1]. In such process, iron could co...
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| Other Authors: | , , |
| Format: | conferenceObject |
| Language: | eng |
| Published: |
2015
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| Subjects: | |
| Online Access: | http://hdl.handle.net/10400.18/3129 |
| Country: | Portugal |
| Oai: | oai:repositorio.insa.pt:10400.18/3129 |
| Summary: | Atherosclerosis is currently considered as a chronic inflammatory disease, in which the subendothelial accumulation of macrophages and their differentiation in lipid−laden foam cells through the uptake of oxidized LDL (oxLDL) constitute key events in atherogenesis [1]. In such process, iron could constitute a modifiable factor [2] and characterization of the iron metabolism profile of the different macrophages phenotypes present in atherosclerotic lesions may provide insight on their potential protective or proatherogenic role. A new macrophage phenotype (Mox) driven by exposure to oxidized phospholipids was recently described in murine models of atherosclerosis [3]. Herein, we investigated the effect of oxLDL as well as proinflammatory stimuli on macrophage polarization and iron metabolism profile. |
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