Increase of aerobic glycolysis mediated by activated T helper cells drives synovial fibroblasts towards an inflammatory phenotype: new targets for therapy?

A dysregulated glucose metabolism in synovial fibroblasts (SF) has been associated with their aggressive phenotype in rheumatoid arthritis (RA). Even though T helper (Th) cells are key effector cells in the propagation and exacerbation of synovitis in RA, little is known about their influence on the...

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Bibliographic Details
Main Author: Kvacskay, Peter (author)
Other Authors: Yao, Nina (author), Schnotz, Jürgen-Heinz (author), Scarpone, Roberta (author), Carvalho, Rui de Albuquerque (author), Klika, Karel D. (author), Merkt, Wolfgang (author), Tretter, Theresa (author), Lorenz, Hanns-Martin (author), Tykocinski, Lars-Oliver (author)
Format: article
Language:eng
Published: 2021
Subjects:
Rheumatoid arthritis
Synovial fibroblasts
Fibroblast-like synoviocytes
T lymphocytes
T helper cells, Metabolism
Glycolysis
Janus kinases
Inflammation
Translational research
Cells, Cultured
Humans
Phenotype
T-Lymphocytes, Helper-Inducer
Fibroblasts
Synovial Membrane
Online Access:http://hdl.handle.net/10316/103729
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/103729

Internet

http://hdl.handle.net/10316/103729

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