To hit or not to hit: large-scale sequence analysis and structure characterization of influenza A NS1 unlocks new antiviral target potential

Influenza NS1 protein is among the most promising novel druggable anti-influenza target, based on its structure; multiple interactions; and global function in influenza replication and pathogenesis. Notwithstanding, drug development guidance based on NS1 structural biology is lacking. Here, we desig...

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Detalhes bibliográficos
Autor principal: Trigueiro-Louro, João M. (author)
Outros Autores: Correia, Vanessa (author), Santos, Luís A. (author), Guedes, Rita C. (author), Brito, Rui M.M. (author), Rebelo-de-Andrade, Helena (author)
Formato: article
Idioma:eng
Publicado em: 2020
Assuntos:
Antiviral Agents
Binding Sites
Computational Biology
Conserved Sequence
Drug Development
Humans
Influenza A virus
Protein Binding
Protein Conformation
Viral Nonstructural Proteins
Drug Design
Resistência aos Antimicrobianos
Infecções Respiratórias
Texto completo:http://hdl.handle.net/10400.18/6649
País:Portugal
Oai:oai:repositorio.insa.pt:10400.18/6649

Texto Completo

http://hdl.handle.net/10400.18/6649

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