Crucial role of oncogenic KRAS mutations in apoptosis and autophagy regulation: therapeutic implications

KRAS, one of the RAS protein family members, plays an important role in autophagy and apoptosis, through the regulation of several downstream effectors. In cancer cells, KRAS mutations confer the constitutive activation of this oncogene, stimulating cell proliferation, inducing autophagy, suppressin...

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Detalhes bibliográficos
Autor principal: Ferreira, Anabela (author)
Outros Autores: Pereira, Flávia (author), Reis, Celso (author), Oliveira, Maria José (author), Sousa, Maria João (author), Preto, Ana (author)
Formato: article
Idioma:eng
Publicado em: 2022
Assuntos:
KRAS mutations
cell death resistance
apoptosis
autophagy
Ciências Médicas::Medicina Clínica
Science & Technology
Texto completo:https://hdl.handle.net/1822/80207
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/80207

Texto Completo

https://hdl.handle.net/1822/80207

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