Crucial role of oncogenic KRAS mutations in apoptosis and autophagy regulation: therapeutic implications

KRAS, one of the RAS protein family members, plays an important role in autophagy and apoptosis, through the regulation of several downstream effectors. In cancer cells, KRAS mutations confer the constitutive activation of this oncogene, stimulating cell proliferation, inducing autophagy, suppressin...

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Bibliographic Details
Main Author: Ferreira, Anabela (author)
Other Authors: Pereira, Flávia (author), Reis, Celso (author), Oliveira, Maria José (author), Sousa, Maria João (author), Preto, Ana (author)
Format: article
Language:eng
Published: 2022
Subjects:
KRAS mutations
cell death resistance
apoptosis
autophagy
Ciências Médicas::Medicina Clínica
Science & Technology
Online Access:https://hdl.handle.net/1822/80207
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/80207

Internet

https://hdl.handle.net/1822/80207

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