Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets

Here we describe a chemical biology strategy performed in Staphylococcus aureus and Staphylococcus epidermidis to identify MnaA, a 2-epimerase that we demonstrate interconverts UDP-GlcNAc and UDP-ManNAc to modulate substrate levels of TarO and TarA wall teichoic acid (WTA) biosynthesis enzymes. Gene...

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Detalhes bibliográficos
Autor principal: Mann, Paul A. (author)
Outros Autores: Müller, Anna (author), Wolff, Kerstin A. (author), Fischmann, Thierry (author), Wang, Hao (author), Reed, Patricia (author), Hou, Yan (author), Li, Wenjin (author), Müller, Christa E. (author), Xiao, Jianying (author), Murgolo, Nicholas (author), Sher, Xinwei (author), Mayhood, Todd (author), Sheth, Payal R. (author), Mirza, Asra (author), Labroli, Marc (author), Xiao, Li (author), McCoy, Mark (author), Gill, Charles J. (author), Pinho, Mariana G. (author), Schneider, Tanja (author), Roemer, Terry (author)
Formato: article
Idioma:eng
Publicado em: 2020
Assuntos:
Microbiology
Parasitology
Virology
Immunology
Genetics
Molecular Biology
Texto completo:http://hdl.handle.net/10362/93081
País:Portugal
Oai:oai:run.unl.pt:10362/93081

Texto Completo

http://hdl.handle.net/10362/93081

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