Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets

Here we describe a chemical biology strategy performed in Staphylococcus aureus and Staphylococcus epidermidis to identify MnaA, a 2-epimerase that we demonstrate interconverts UDP-GlcNAc and UDP-ManNAc to modulate substrate levels of TarO and TarA wall teichoic acid (WTA) biosynthesis enzymes. Gene...

Full description

Bibliographic Details
Main Author: Mann, Paul A. (author)
Other Authors: Müller, Anna (author), Wolff, Kerstin A. (author), Fischmann, Thierry (author), Wang, Hao (author), Reed, Patricia (author), Hou, Yan (author), Li, Wenjin (author), Müller, Christa E. (author), Xiao, Jianying (author), Murgolo, Nicholas (author), Sher, Xinwei (author), Mayhood, Todd (author), Sheth, Payal R. (author), Mirza, Asra (author), Labroli, Marc (author), Xiao, Li (author), McCoy, Mark (author), Gill, Charles J. (author), Pinho, Mariana G. (author), Schneider, Tanja (author), Roemer, Terry (author)
Format: article
Language:eng
Published: 2020
Subjects:
Microbiology
Parasitology
Virology
Immunology
Genetics
Molecular Biology
Online Access:http://hdl.handle.net/10362/93081
Country:Portugal
Oai:oai:run.unl.pt:10362/93081

Internet

http://hdl.handle.net/10362/93081

Similar Items