Unveiling paracrine dissemination and toxicity of neuronal TrkB-ICD via secretome signalling in Alzheimer’s disease

The brain-derived neurotrophic factor (BDNF) is a neurotrophin that binds to the TrkB full-length receptor (TrkB-FL), triggering cascades responsible for neuroprotection. This BDNF/TrkB-FL system is known to be impaired in Alzheimer’s disease (AD)due to an amyloid-β-mediated TrkB-FL cleavage, leadin...

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Detalhes bibliográficos
Autor principal: Coelho, Tiago Rodrigo da Costa (author)
Formato: masterThesis
Idioma:eng
Publicado em: 2021
Assuntos:
Alzheimer’s disease
TrkB-FL
TrkB-ICD
extracellular vesicles
TAT-TrkBpeptide
5xFAD model
Domínio/Área Científica::Ciências Médicas
Texto completo:http://hdl.handle.net/10362/123379
País:Portugal
Oai:oai:run.unl.pt:10362/123379

Texto Completo

http://hdl.handle.net/10362/123379

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