Synthesis of Carbocyclic Pyrimidine Nucleosides Using the Mitsunobu Reaction: O2- vs. N1-Alkylation

The Mitsunobu reaction is an important tool in carbocyclic nucleoside chemistry for the direct coupling of alcohols with heterocyclic bases under mild conditions. Chemical evidences for an unusual competitive O2- vs. N1-alkylation of 3-substituted pyrimidines is presented.

Bibliographic Details
Main Author: Elías Quezada (author)
Other Authors: Dolores Viña (author), Giovanna Delogu (author), Fernanda Borges (author), Lourdes Santana (author), Eugenio Uriarte (author)
Format: article
Language:eng
Published: 2010
Subjects:
Online Access:https://hdl.handle.net/10216/96758
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/96758