Synthesis of Carbocyclic Pyrimidine Nucleosides Using the Mitsunobu Reaction: O2- vs. N1-Alkylation

The Mitsunobu reaction is an important tool in carbocyclic nucleoside chemistry for the direct coupling of alcohols with heterocyclic bases under mild conditions. Chemical evidences for an unusual competitive O2- vs. N1-alkylation of 3-substituted pyrimidines is presented.

Detalhes bibliográficos
Autor principal: Elías Quezada (author)
Outros Autores: Dolores Viña (author), Giovanna Delogu (author), Fernanda Borges (author), Lourdes Santana (author), Eugenio Uriarte (author)
Formato: article
Idioma:eng
Publicado em: 2010
Assuntos:
Química orgânica, Engenharia química
Organic chemistry, Chemical engineering
Texto completo:https://hdl.handle.net/10216/96758
País:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/96758
Descrição
Resumo:The Mitsunobu reaction is an important tool in carbocyclic nucleoside chemistry for the direct coupling of alcohols with heterocyclic bases under mild conditions. Chemical evidences for an unusual competitive O2- vs. N1-alkylation of 3-substituted pyrimidines is presented.

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