Novel candidate blood-based transcriptional biomarkers of Machado-Joseph disease

BACKGROUND: Machado-Joseph disease (or spinocerebellar ataxia type 3) is a late-onset polyglutamine neurodegenerative disorder caused by a mutation in the ATXN3 gene, which encodes for the ubiquitously expressed protein ataxin-3. Previous studies on cell and animal models have suggested that mutated...

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Detalhes bibliográficos
Autor principal: Raposo, Mafalda (author)
Outros Autores: Bettencourt, Conceição (author), Maciel, P. (author), Gao, Fuying (author), Ramos, Amanda (author), Kazachkova, Nadiya (author), Vasconcelos, João (author), Kay, Teresa (author), Rodrigues, Ana João (author), Bettencourt, Bruno (author), Bruges-Armas, Jácome (author), Geschwind, Daniel (author), Coppola, Giovanni (author), Lima, Manuela (author)
Formato: article
Idioma:eng
Publicado em: 2015
Assuntos:
Spinocerebellar ataxia type 3
Polyglutamine disease
Gene expression
Ataxin-3
Microarray
Science & Technology
Texto completo:http://hdl.handle.net/1822/42783
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/42783

Texto Completo

http://hdl.handle.net/1822/42783

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