Optimal control of a fractional order epidemic model with application to human respiratory syncytial virus infection

A human respiratory syncytial virus surveillance system was implemented in Florida in 1999, to support clinical decision-making for prophylaxis of premature newborns. Recently, a local periodic SEIRS mathematical model was proposed in [Stat. Optim. Inf. Comput. 6 (2018), no.1, 139--149] to describe...

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Detalhes bibliográficos
Autor principal: Rosa, Silvério (author)
Outros Autores: Torres, Delfim F. M. (author)
Formato: preprint
Idioma:eng
Publicado em: 2020
Assuntos:
Texto completo:http://hdl.handle.net/10400.6/9034
País:Portugal
Oai:oai:ubibliorum.ubi.pt:10400.6/9034
Descrição
Resumo:A human respiratory syncytial virus surveillance system was implemented in Florida in 1999, to support clinical decision-making for prophylaxis of premature newborns. Recently, a local periodic SEIRS mathematical model was proposed in [Stat. Optim. Inf. Comput. 6 (2018), no.1, 139--149] to describe real data collected by Florida's system. In contrast, here we propose a non-local fractional (non-integer) order model. A fractional optimal control problem is then formulated and solved, having treatment as the control. Finally, a cost-effectiveness analysis is carried out to evaluate the cost and the effectiveness of proposed control measures during the intervention period, showing the superiority of obtained results with respect to previous ones.